Poster E26, Monday, March 26, 2:30-4:30 pm, Exhibit Hall C
Cognitive flexibility tracks with dynamic transitions in intrinsic connectivity profiles
Shruti Vij1, Lucina Uddin1,2; 1Department of Psychology, University of Miami, 2Neuroscience Program, University of Miami Miller School of Medicine
Cognitive flexibility is a dynamic property of executive functioning that enables individuals to efficiently switch between mental processes. Recent advances in resting state functional magnetic resonance imaging (rs-fMRI) indicate that dynamic properties of the brain at rest may be associated with flexible cognition. However, the association between cognitive flexibility and brain dynamics have not been explicitly evaluated across the lifespan. Using a large publicly available rs-fMRI dataset (n = 187; age range = 6-85 years), we find that dynamic properties of functional connections measured over 10 minutes were significantly associated with the time it takes to correctly identify the “Odd Man Out” amongst four objects outside the scanner. Specifically, the number of transitions between five identified brain states increases as the reaction time for the correct response in the Penn Conditional Exclusion test increases. Performance on the Penn Conditional Exclusion test was also found to have unique patterns of age related changes in the features of brain dynamics. The number of transitions between the states linearly increases with age, and the frequency of occurrence and the dwell time of particular states linearly and quadratically increase with age. These results suggest that dynamic properties of intrinsic network interactions underlie individual differences in the ability to switch between cognitive tasks, and that is in turn dependent on cognitive aging.
Topic Area: EXECUTIVE PROCESSES: Development & aging