Poster Session F, Tuesday, March 26, 8:00 – 10:00 am, Pacific Concourse
White Matter Organization and Metacognitive Monitoring in Traumatic Brain Injury
Kathy S. Chiou1, Jeremy A. Feiger1, Mackenzie Cissne1; 1University of Nebraska-Lincoln
Disruptions to white matter (WM) organization are related to cognitive deficits observed following traumatic brain injury (TBI). To date, investigations of WM organization and cognition in TBI have focused on domains such as memory and executive functioning. However, less is known about the role of WM organization in supporting metacognitive processes after TBI. The purpose of this study is to determine the relationship between WM organization and metacognition after TBI. 15 adults with moderate/severe TBI and 9 healthy controls completed a working memory task, whereby a metacognitive confidence judgment was collected after each task item. Metacognitive performance was determined by area under the curve (AUC) analyses of task accuracy and confidence judgments. Participants also completed a 64-direction diffusion tensor imaging (DTI) scan. Metacognitive performance was included as a covariate in a mixed linear model to determine between-group differences. Family-wise error correction was applied at p<0.05. In adults with TBI, metacognitive performance was found to be positively correlated with WM organization near the right supramarginal gyrus. Healthy controls showed additional relationships between metacognitive performance and WM organization in the corpus callosum bilaterally, the right superior corona radiata near the cingulate, left superior longitudinal fasciculus, left cingulum, and left posterior corona radiata near the cingulate. The findings indicate that WM organization associated with metacognitive performance differ between adults with TBI and healthy peers. Implications of the close proximity between regions of WM associated with metacognitive function found in this study and functional structures previously identified in the literature will be discussed.
Topic Area: EXECUTIVE PROCESSES: Other