Poster Session E, Monday, March 25, 2:30 – 4:30 pm, Pacific Concourse
Distinct regions of the human hippocampus are associated with memory for different spatial locations.
Brittany Jeye1, Sean MacEvoy1, Scott Slotnick1; 1Boston College
In the present functional magnetic resonance imaging (fMRI) study, we evaluated whether distinct regions of the hippocampus were associated with spatial memory for items presented in different locations of the visual field. During encoding, participants maintained fixation and viewed abstract shapes presented in the upper-right quadrant, the lower-right quadrant, the upper-left quadrant, or the lower-left quadrant. During retrieval, old shapes were presented at fixation and participants classified each shape as previously in the “upper-right”, “lower-right”, “upper-left”, or “lower-left”. Analyses revealed that accurate spatial memory for shapes in each quadrant of the visual field was associated with distinct hippocampal sub-regions (identified by contrasting hits > misses for each quadrant). For instance, accurate spatial memory for shapes in the upper-right quadrant was associated with activity in hippocampal sub-regions that were distinct from the hippocampal sub-regions associated with accurate spatial memory for shapes in the lower-right, upper-left, and lower-left quadrants. A multi-voxel pattern analysis (MVPA) of hippocampal activity revealed a significant correlation between behavioral spatial location accuracy and hippocampal MVPA accuracy across participants. The present results indicate that unique hippocampal regions are associated with different visual field locations during memory and that patterns of activity in the hippocampus contain information about spatial location.
Topic Area: LONG-TERM MEMORY: Episodic