Poster Session D, Monday, March 25, 8:00 – 10:00 am, Pacific Concourse
Disrupted executive control in schizophrenia: neural mechanisms revealed by event-related potentials and frontal midline theta oscillations
Xiangfei Hong1,2, Wei Li1, Jiangling Jiang1, Hongyan Wang1, Jiaqi Wang3, Jianan Wang3, Wenzheng Wang1, Jianhua Sheng1, Jijun Wang1, Chunbo Li1; 1Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 2J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA, 3School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, China
Deficits in executive control have been widely regarded as one of the hallmark cognitive characteristics in schizophrenia. In this study, we recorded 64-channel scalp electroencephalography (EEG) from 30 schizophrenia patients (SZs; 17 women; mean age: 30.4 years) and 31 healthy control subjects (HCs; 17 women; mean age: 29.1 years) while performing a combined flanker-Go/NoGo task. We investigated the neural mechanisms of two core components in executive control, i.e., conflict suppression and response inhibition, by examining event-related potentials (ERPs) and frontal midline theta (FMθ) oscillations. We found that SZs showed significantly lower behavioral accuracy than HCs, but only in incongruent and NoGo task conditions. We also found that SZs showed decreased amplitudes of conflict-related N2 component and inhibition-related P3 component than HCs. Furthermore, although both HCs and SZs showed increased FMθ under incongruent and NoGo conditions, the magnitudes of such FMθ modulation were significantly reduced in SZs than that in HCs. In the HC group, we observed a positive correlation between FMθ and behavioral accuracy in the incongruent condition, but not in the NoGo condition. While in the SZ group, this correlation was observed in the NoGo condition, but not in the incongruent condition. The amplitudes of N2 and P3 components, however, were not correlated with behavioral accuracy in either group. Taken together, our results suggested a underlying neural mechanism consisting of impaired N2, P3 and FMθ for executive control deficits in SZs, and that the role of FMθ in SZs might vary according to the type of executive control required.
Topic Area: EXECUTIVE PROCESSES: Monitoring & inhibitory control