Poster Session C, Sunday, March 24, 5:00 – 7:00 pm, Pacific Concourse
The effects of CBT-I on Cognitive Functioning in individuals with Insomnia and Mild Cognitive Impairment
Kathleen O'Hora1, Clara Lee1, Alison Buchanan1, Beatriz Hernandez1,2, Jamie M. Zeitzer1,2, Leah Friedman1,2, Donn Posner1,2, Clete Kushida1, Jerome A. Yesavage1,2, Andrea N. Goldstein-Piekarski1,2; 1Mental Illness Research Education and Clinical Center, VA Palo Alto Health Care System, Palo Alto, CA, USA., 2Stanford University, Stanford, CA, USA.
Insufficient sleep, a common condition in older adults with mild cognitive impairment (MCI), may exacerbate cognitive impairments, potentially representing a causal factor and treatment target for MCI. We extend a recent study that demonstrated that Cognitive Behavioral Therapy for Insomnia (CBT-I) improves both sleep and cognitive functioning in older individuals with comorbid insomnia and MCI by utilizing a study of components of CBT-I. Eighty-five adults (mean age=68.75 34% male) with insomnia completed the Montreal Cognitive Assessment (MoCA) at baseline to determine cognitive status. MCI was defined as MoCA < 26. In addition, the Insomnia Severity Index (ISI), and a cognitive battery which included tasks assessing inhibition, task-switching, verbal memory recall and recognition, and overall cognitive functioning (trail making) were administered at baseline and six months after receiving either the behavioral, cognitive, or both components of CBT-I treatment. 21(25%) participants were classified as having MCI. Two-way repeated measures ANOVAs with one within (time) and one between (MCI status) subject factors revealed significant main effects of time in reducing ISI (p<0.0001), marginally improving inhibition (p=0.0501), verbal memory recall (p=0.01563), story recall (p=0.0007648), and trails task performance (p=0.0019) across all participants. There were no significant time x MCI status interaction effects for these measures (p’s>0.05). These findings replicate and extend work demonstrating that non-pharmacological insomnia treatments can improve insomnia symptoms and may improve cognitive abilities in individuals with and without MCI. They also add additional support to the hypothesis that sleep is an intervention target for improving cognitive abilities in those with insomnia.
Topic Area: EXECUTIVE PROCESSES: Development & aging