Poster Session F, Tuesday, March 26, 8:00 – 10:00 am, Pacific Concourse
Neural correlates of guilty feelings in young adults
Seishu Nakagawa1,2, Hikaru Takeuchi2, Yasuyuki Taki2, Rui Nouchi2, Yuka Kotozaki2, Takamitsu Shinada2, Tsukasa Maruyama2, Atsushi Sekiguchi2,3, Kunio Iizuka2, Ryoichi Yokoyama4, Yuki Yamamoto2, Ryuta Kawashima2; 1Tohoku Medical and Pharmaceutical University, Sendai, Japan, 2Tohoku University, 3National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan, 4Kobe University
Feelings of guilt are associated with self and social cognitions. Deontological guilt is derived from the transgression of social and moral norms according to inner values, whereas altruistic guilt arises from the appraisal of altruistic situations. We hypothesized that the brain structures involved in feelings of guilt are also associated with regions related to self and social cognitions. We investigated the association between regional gray matter density (rGMD) or regional mean diffusivity (MD) using MRI and the guilty feeling scale (GFS) which comprises interpersonal situation (IPS; references altruistic guilt) and rule-breaking situation (RBS; references deontological guilt) scores in healthy young students (20.7 ± 1.8 years; rGMD: 422 males, 342 females; MD: 686 males, 510 females). Importantly, there were two novel findings. One is that both the IPS and RBS were negatively related to the rGMD in the right posterior insula (PI) as a common region for feelings of guilt. The other is that MD in the right somatosensory and motor cortices from arm to hand were positively correlated with RBS scores, as would be predicted by the Macbeth effect. Further, the IPS scores were negatively correlated with rGMD in the left anterior insula (AI), and right inferior parietal lobule (IPL). Moreover,the RBS scores were positively correlated with MD in the bilateral IPL, the right prefrontal regions, and the left posterior cingulate region, in accordance with our hypothesis.
Topic Area: EMOTION & SOCIAL: Person perception