Poster Session F, Tuesday, March 26, 8:00 – 10:00 am, Pacific Concourse
Neural pattern change during repeated memory encoding.
Minjae Kwon1, Sue-Hyun Lee1,2; 1Department of Bio and Brain Engineering, College of Engineering, Korea Advanced Institute of Science and Technology, 2Program of Brain and Cognitive Engineering, College of Engineering, Korea Advanced Institute of Science and Technology
Learning by repetition is a useful strategy for semantic memory acquisition. Association areas including the angular gyrus have been thought to be critical for the information integration process during memory encoding, but it remains elusive whether the moment-to-moment changes of the responses in the association areas reflect associative learning. Here, we used functional magnetic resonance imaging (fMRI) and multi-voxel pattern analysis to investigate the representation of integrative information during associative learning task. In the task, during the scan, participants learned pairs of images (object or building images) and person’s names. While each image-name association was learned individually, an object image and a building image were associated with a common name. The participants showed progressive improvement in recall performance over the repeated trials. Using trial-by-trial similarity analysis, we found that between-stimulus pattern similarity for the associated object-building pairs was significantly higher than that for non-associated pairs at the 4th trial in the left angular gyrus. Moreover, this similarity was significantly greater than that of the earlier trials. The between-stimulus pattern similarity for the non-associated pairs was comparable across the trials. These results suggest that repeated associative learning elicit changes of the neural similarity patterns in the angular gyrus and that the increase of the pattern similarity underlies the storage of the associative information.
Topic Area: LONG-TERM MEMORY: Semantic