Poster Session E, Monday, March 25, 2:30 – 4:30 pm, Pacific Concourse
EEG network coherence in the 40 Hz gamma band modulates attentional state and task performance
Ka Eun Lee1,2, Hio-Been Han1,3, Jee Hyun Choi1,4; 1Korea Institute of Science and Technology, 2Seoul National University, 3Korea Advanced Institute of Science and Technology, 4Korea University of Science and Technology
Cognitive operations that use external cues to guide behavior require sustained attention, which is mediated by several brain regions. The basal forebrain (BF) increases acetylcholine release in the PFC to enhance attention, while in the PFC, the emergence of gamma oscillations (~40 Hz) during attention has been known to form a task-positive dorsal-attentional network with the post-parietal cortex (PPC). However, recent findings associated the BF-PFC gamma network with a task-negative state, highlighting the lack of understanding of gamma oscillations and their influence on sustained attention. Here, using a Sustained Attention to Response Task, we investigated pre-stimulus gamma and their long-range synchrony in mice during distinct attentional states. We first identified attentive (active engagement) and inattentive (long-term disengagement) states based on short-term performance, and discovered that pre-stimulus PFC/BF gamma are stronger in inattentive states, supporting more recent findings. However, when we further classified attentive states into correct and error (momentary attentional lapse) trials, PFC/BF gamma were stronger in correct trials, consistent with earlier findings. Together, these results reveal a non-linear relationship between gamma amplitude and performance. Interestingly, while PFC-PPC synchrony was stronger in correct trials, BF-PFC synchrony was stronger in error trials despite weaker amplitudes, implying the involvement of the BF-to-PFC gamma network during an attentional lapse. Taken together, these findings indicate that stronger BF/PFC gamma does not necessarily predict better performance, but rather that coherence within gamma networks may be the key to understanding the role of gamma oscillations in sustained attention and task performance.
Topic Area: EXECUTIVE PROCESSES: Monitoring & inhibitory control