Poster C20, Sunday, March 26, 5:00 – 7:00 pm, Pacific Concourse
Common Neural Substrates of Down-Regulating Negative Emotion and Social Threat
Teodora Stoica1, Lindsay Knight1, Leonard Faul1, Farah Naaz1, Brendan Depue; 1University of Louisville
The relationship between the neural mechanisms underlying regulation of negative emotion and social threat perception and has not been fully elucidated. The current fMRI study aimed to investigate common mechanisms underlying the down-regulation of negative emotion and social threat perception. FMRI data was correlated with subjective behavioral ratings of negative pictures as well as fearful human faces. In addition, independent component analysis (ICA) was used to extract common networks during an emotion regulation (ER) and social threat task (STT). Behavioral results showed that ratings from the ER and STT correlated strongly. Functional results indicated a similar pattern of activation in the right hemisphere for both tasks, with robust activation in the inferior frontal junction (IFJ), medial frontal gyrus (MFG) and inferior frontal gyrus (IFG). Functional data correlated with behavioral ER ratings revealed increased rIFG and bilateral inferior parietal sulci (IPS) for better down-regulation, as well as decreased amygdala activation during the STT. Results using ICA analysis indicated common components across tasks, which loaded heavily on the right IFJ, IFG and lateral inferior parietal cortex. Selected components were also found to predict behavioral ER and STT ratings, whereby higher expression of components was related to more down regulation of negative emotion and social threat perception, respectively. The results suggest higher utilization of indicated functional networks and brain regions is related to a higher rate of down-regulating negative emotion and social threat perception.
Topic Area: EMOTION & SOCIAL: Emotion-cognition interactions