Poster B25, Sunday, March 26, 8:00 – 10:00 am, Pacific Concourse
Neural Activation Accompanying Emotional Judgments of Faces by Latino Youth-At-Risk for Bipolar Disorder
Kareem Al-Khalil1, Hugo Sandoval2, Michael Escamilla2, Karl Kashfi3, Luis Ramos-Duran2, Ivette Noriega1, Desiree Walisky1,3, Ravi Rajmohan3, Michael O'Boyle1,3; 1Texas Tech University, Lubbock, 2Texas Tech University Health Sciences Center Paul L. Foster School of Medicine, El Paso, 3Texas Tech University Health Sciences Center, Lubbock
Individuals with bipolar disorder (BD) are known to exhibit difficulties with emotional processes, particularly with regard to detecting emotions depicted in human faces (Adleman, et al., 2013). Moreover, this deficiency is under explored in those of Latino descent, who are considered to be at high risk for BD (Sandoval, et al, 2016). In this study 5 Latino youth-at-risk (YAR) and 5 Latino not-at-risk (YNAR) controls (matched for age and sex) underwent functional magnetic resonance imaging (fMRI) while making same/different judgments of chimeric face pairs that depicted a variety of emotions. YAR were less accurate (76%) than the YNAR (95%) when making these facial determinations (x2 =14.56, p < .001); reaction times did not differ between groups. Additionally, the YAR showed a larger number and more diffuse locations of brain activation, with hyper-activation of the fusiform gyrus, along with greater activation of several regions comprising the Automatic/Internal Emotional Regulatory Network (e.g., thalamus, putamen, pallidum and cingulate; see Maletic & Raison, 2014). These findings indicate that Latino YAR for BD have difficulty in processing faces and detecting their corresponding emotions. Such difficulties are reflected in compensatory brain activations that are likely designed to bolster face processing and the extraction of their emotional valence. These results are discussed in light of their use as potential neural markers of BD in at-risk Latino youth, even for those who do not yet clinically manifest BD symptomatology.
Topic Area: EMOTION & SOCIAL: Emotion-cognition interactions