Poster B72, Sunday, March 26, 8:00 – 10:00 am, Pacific Concourse
Lesion Analysis of Single-Word Auditory Comprehension in 109 Patients
Juliana Baldo1, Carl Ludy1, Brian Curran1, And Turken1, Nina Dronkers1,2; 1VA Northern California Health Care System, 2University of California, Davis
In the current study, we sought to better understand the neural basis of single-word auditory comprehension. Previous studies have produced mixed results with respect to the brain regions involved in this process, primarily implicating various areas in the left middle and superior temporal gyri (MTG and STG). From our database, we identified 109 chronic left hemisphere stroke patients (10 female) who met strict inclusion and exclusion criteria. Single-word auditory comprehension data from the Western Aphasia Battery were analyzed retrospectively and correlated with patients’ lesion sites using voxel-based lesion symptom mapping (VLSM). For the auditory comprehension task, patients were asked to point to 60 different objects, drawings, and body parts (e.g., cup, flower, right shoulder). Patients’ language and auditory comprehension deficits ranged from very mild to severe. For the VLSM analysis, we used a relatively conservative method (permutation testing) to generate a significant t-value cutoff score with which to evaluate the significance of the findings. The analysis only included voxels in which at least five patients had lesions, and statistical power was high in the left MTG and STG, the focus of the study. The results of the VLSM analysis showed that the maximum t-value of 7.51 was located in the left posterior MTG (-40, -70, 8). Additional significant voxels were primarily focused along the axis of the left MTG, from middle to posterior MTG. These data indicate a critical role for the left MTG, most specifically the posterior left MTG, for the processing of single words.
Topic Area: LANGUAGE: Semantic