Poster B105, Sunday, March 26, 8:00 – 10:00 am, Pacific Concourse
Age-related changes to hippocampal and neocortical oscillations during relational binding and comparison.
Renante Rondina1,2, Rosanna Olsen1, Morgan Barense2, Jed Meltzer1,2, Jennifer Ryan1,2; 1Rotman Research Institute, 2University of Toronto
Recent models of hippocampal function have emphasized its role in relational binding and comparison – the ability to form lasting representations regarding the relations among distinct elements, and the ability to evaluate current perceptual input to previously formed representations, respectively. The present study used magnetoencephalography to examine the extent to which aging is associated with changes in the recruitment of oscillatory activity within hippocampal and neocortical regions to support relational binding, maintenance, and comparison processes during a short delay visuospatial memory task. Participants were required to bind the relative visuospatial positions of objects that were presented singly across time. After a 2 second delay, the objects were re-presented simultaneously, and participants were required to indicate whether the relative spatial positions among the objects had been maintained. Younger and older adults performed with similar accuracy. Over the encoding period, younger adults uniquely showed a change in theta power (~5 Hz), whereas older adults uniquely showed a change in alpha (~10 Hz) power. Over the maintenance period, younger and older adults showed similar theta, alpha, and beta (~20 Hz) activity. Over the retrieval period, older adults showed a stronger theta, alpha, and beta response than younger adults. These findings provide novel evidence for the role of the hippocampus and functionally connected regions in relational binding and comparison that is affected by aging. The present findings are discussed in the context of current models regarding the cognitive neuroscience of aging.
Topic Area: LONG-TERM MEMORY: Other