Poster B46, Sunday, March 26, 8:00 – 10:00 am, Pacific Concourse
Cortical markers show differences in areas sustaining inhibitory control between children and adults
Marine Moyon1, Katell Mevel1, Lisa Delalande1, François Orliac1, Sonia Dollfus2,3, Olivier Houdé1,4, Carole Peyrin5, Wim De Neys1, Nicolas Poirel1,4, Grégoire Borst1, Gregory Simon1; 1LaPsyDÉ, UMR 8240, CNRS, Université Paris Descartes, Université de Caen Normandie, France, 2ISTS, UMR 6301, CNRS, CEA, Caen, France, 3CHU de Caen, Service de Psychiatrie, Centre Esquirol, Caen, France, 4Institut Universitaire de France (IUF), Paris, 5LPNC, UMR 5105, CNRS, Université Pierre Mendès France, France
Because inhibitory control (IC) efficiency in childhood is a strong predictor of academic successes later in life, capturing its neurodevelopmental outcome is crucial. In order to provide a better overview of the gray matter ontogenetic changes accompanying IC development, we analyzed various markers (thickness, surface, volume, curvature) from anatomical MRI brain images collected in 23 healthy children (10,7 ± 0,86 years old, 11 girls ) and 40 adults (25,8 ± 5,9 years old, 19 women). We focused on these particular quantitative markers as they respond to different genetic constraints and may point toward different developmental mechanisms (Panizzon et al., 2009). In order to perform multiple linear regression analysis with a Stroop score, we used Freesufer software to extract measures from three regions of interest (ROI) selected for their involvement in IC: left and right medial orbito-frontal (MOF), left anterior cingulate cortex (ACC). At behavioral level, a significant Stroop effect was seen in children (p<.001) and adults (p<.001), for which adults were better inhibitors than children (p<.001). Whereas no correlation was seen in ACC, IC efficiency was significantly associated to a broader cortical surface in left (p<.05) and right MOF (p<.01) in the best adult inhibitors only. The present results showed a distinct pattern of brain anatomical properties in children and adults in inhibitory areas. Following the postero-anterior gradient hypothesis of brain development, children may have a still diffuse and immature frontal network, not allowing them to reach the performances of the adults.
Topic Area: EXECUTIVE PROCESSES: Monitoring & inhibitory control