Poster E91, Monday, March 27, 2:30 – 4:30 pm, Pacific Concourse
Ecological assessment of retrospective and prospective memory in early Alzheimer’s disease: validity of a virtual reality task
Valentina La Corte1,2,4, Valentine Facque1,2, Maria Abram1,2, Agnès Michon4, Aurélie Funkiewiez4, Bruno Dubois4,5, Pascale Piolino1,2,3; 1Institute of Psychology, University Paris Descartes, Sorbonne Paris Cite, France, 2Inserm UMR 894, Center of Psychiatry and Neurosciences, Memory and Cognition Laboratory, Paris, France, 3University Institute of France, Paris, France, 4Institut de la Mémoire et de la Maladie d’Alzheimer (IM2A), Départment de Neurologie, Hôpital Pitié-Salpêtrière, AP-HP, Paris, France, 5Institut du Cerveau et de la Moelle Epinière (ICM), CNRS UMR 7225- INSERM U1127 Paris, France; Sorbonne Universités, Université Pierre et Marie Curie-Paris 6, Paris, France
Retrospective memory (RM) involves remembering previous events or previously learned information. Prospective memory (PM) is the ability to form, maintain and execute intended actions after a delay, in the appropriate context in the future. According to the context of the intention retrieval, three different types of PM have been defined: time-based (TB), event-based (EB), and activity-based (AB) actions. Classical neuropsychological tools used to assess these two types of memory are far from what we experience in daily life. The aim of this study is to investigate the cognitive mechanisms underlying prospective and retrospective memory impairments in Alzheimer’s disease (AD) patients using a naturalistic environment crated with virtual reality (VR). Participants walk in a virtual town, then perform a retrospective (RT) and a prospective memory tasks (PT). Results show that AD patients are impaired in both tasks. Nevertheless they are more impaired in the RT compared to the PT. In particular within the RT they show a severe deficit in feature binding (the association between what, where, when) in line with previous studies. Within the PT they are deeply impaired in TB tasks but interestingly they show significantly better performance in AB actions, in which they are asked to directly act in the VR environment suggesting the benefit of enactment effect in AD. Taken together these findings suggest that virtual environments entail considerable potential for the assessment of retrospective and prospective memory in early AD and they pave the way to future applications in cognitive rehabilitation programs focused on long-term memory.
Topic Area: LONG-TERM MEMORY: Episodic