Poster E94, Monday, March 27, 2:30 – 4:30 pm, Pacific Concourse
Multimodal Investigation of Neurobehavioral Dynamics – MINDs – in Emotional Distraction
Florin Dolcos1, Matthew Moore1, Alexandru Iordan2, Yuta Katsumi1, Ryan Larsen1, Edward Maclin1, Andrea Shafer3, Anthony Singhal4, Brad Sutton1, Andrew Bagshaw5, Monica Fabiani1, Gabriele Gratton1; 1University of Illinois at Urbana-Champaign, 2University of Michigan, 3National Institutes of Health, 4University of Alberta, 5University of Birmingham
The link between spatial (where) and temporal (when) aspects of the neural correlates of most psychological phenomena is not clear. Elucidation of this relation requires integration across multiple brain imaging modalities and tasks that reliably modulate the engagement of brain systems of interest. This poster will illustrate such an integration across 3 imaging modalities: functional magnetic resonance imaging (fMRI), electroencephalography/event-related potentials (EEG/ERP), and event-related optical signals (EROS), which shares the spatial resolution of fMRI and temporal resolution of ERPs. Executive tasks with emotional distraction were used, because such dual-task designs can dissociate between large-scale dorsal and ventral brain systems involved in cognitive and affective processing. Pilot data from subjects performing an emotional odd-ball task provided initial validation of simultaneous fMRI-EEG and EEG-EROS recordings, and identified prefrontal and parietal cortical responses consistent with unimodal spatial and temporal evidence. Additional pilot data extended these results to a combined working memory-emotion regulation task with emotional distraction, and showed further spatio-temporal dissociations convergent across the 3 modalities, in fronto-parietal areas, as a function of the source of distraction (external-percepts vs. internal-memories) and the type of ER (spontaneous vs. instructed). Moreover, EEG-informed fMRI analyses identified links between ERP amplitude at parietal electrodes and fronto-parietal hemodynamic responses when coping with distraction, further supporting the value of multimodal imaging integration. Finally, data resulted from simultaneous fMRI-ERP-EROS recordings further validated the feasibility of using EROS as a bridging tool in this tri-modal combination of brain imaging methods, which is a World Premiere in the study of brain function.
Topic Area: METHODS: Neuroimaging