Poster D81, Monday, March 27, 8:00 – 10:00 am, Pacific Concourse
Modulation of regional activity and inter-regional connectivity during recollection of visual and auditory information
Danielle King1, MIchael Rugg1; 1University of Texas at Dallas
Successful recollection involves enhanced activity (as assessed with fMRI) in both content-general brain regions (the ‘core recollection network’) and in content-specific regions that were also active during encoding. Recent studies have demonstrated that in addition to enhanced activity, core recollection regions also exhibit recollection-related increases in connectivity with a broadly distributed set of brain regions that include both content-general regions (other members of the core network and regions implicated in cognitive control) and content-specific regions such as visual cortex. We hypothesize that the enhanced connectivity observed with content-selective regions reflects their role in ‘reinstating’ encoded information. The goal of the current study is to examine an implication of this hypothesis, namely, that recollection-related enhancement of connectivity between core regions and content-specific areas should vary depending on whether recollected information depends on those areas for its representation. This hypothesis will be examined with psychophysiological interaction (PPI) analyses. Participants were scanned during both encoding and retrieval phases of a source memory task. At study, pictures of objects were presented with either written or spoken words. At test, participants were shown old and new pictures and made old/new recognition judgments and for items judged old they then made source memory judgments (written/spoken). Robust material-selective effects (spoken vs. written) were evident at encoding, along with material-selective ‘subsequent memory’ effects. Similarly robust retrieval success effects were identified at test, along with evidence of content-selective reinstatement. Results from the PPI analyses will be presented.
Topic Area: LONG-TERM MEMORY: Episodic