Poster F45, Tuesday, March 28, 8:00 – 10:00 am, Pacific Concourse
Pre- and Post-treatment Effects on Resting-State Functional Connectivity in Women Diagnosed with Breast Cancer
Omid Kardan1, Scott Peltier2, Bratislav Misic3, Mary Askren4, Misook Jung5, Nathan Churchill6, Patricia Reuter-Lorentz2, Bernadine Cimprich2, Marc Berman1; 1University of Chicago, 2University of Michigan, 3Montreal Neurological Institute, 4University of Washington Seattle, 5Chungnam National University, 6Keenan Research Centre of the Li Ka Shing Knowledge Institute, St. Michael’s Hospital
Previous studies have linked distress, worry, and fatigue associated with cancer diagnosis to decreased functional connectivity and reduced Hurst exponent (H) of the BOLD signal, a measure of scale-free brain dynamics, in brain regions associated with attention and memory. Additionally, chemotherapy patients are reported to have higher spatial variance in executive network fMRI activation than non-chemotherapy (only radiation and/or endocrine therapy) and healthy controls when performing working memory tasks. In this study we investigated functional connectivity in patients treated with (n = 18) or without (n = 22) chemotherapy for localized breast cancer and healthy aged-matched controls (n = 22) during rest (eyes open). fMRI data collection occurred at three time points: diagnosis (M0, pre-adjuvant treatment), at least 1 month (M1), and 7 months (M7) after treatment, chemotherapy/radiation therapy. We used Preprocessing Optimization Toolkit (PRONTO) to preprocess the resting-state data, and then divided the brain into 116 regions using Automated Anatomical Labeling (AAL). Our analysis used Partial Least Squares (PLS) to compare the functional connectivity of the regions among the three time points for each group. Compared to healthy controls, we found a global increase in functional connectivity comparing M1 and M7 for both patient groups, with the radiotherapy group having more wide-spread increase in functional connectivity than the chemotherapy group. Possible reasons for the increases in patients’ resting-state functional connectivity over time such as diminished anxiety/worry is discussed.
Topic Area: EXECUTIVE PROCESSES: Other