Poster F107, Tuesday, March 28, 8:00 – 10:00 am, Pacific Concourse
Treatment induced plasticity of motor and language networks in patients with brain lesions
Nina Sardesh1, Lucia Bulubas2, Tavish Traut1, Danielle Mizuiri1, Susanne Honma1, Coleman Garrett1, Avery Garrett1, Mitchel Berger1, Heidi Kersch1, Phiroz Tarapore1, Srikantan Nagarajan1; 1University of California, San Francisco, 2Technische Universitat Munchen, Munich, Germany
The goal of this work was to examine plasticity of motor and language networks in patients with brain lesions who undergo resective surgery followed by radiation and chemotherapy. Ninety-nine patients with grade II-IV lesions underwent preoperative mapping with language and motor tasks on two occasions up to eight years apart due to tumor recurrence. This study focuses on the comparison of preoperative magnetoencephalography brain activation profiles across multiple visits on a group level. The examine motor networks, we examined activation maps during movement preparation for left and right index finger. Spatial analysis of preparatory activity maps for RD2 and LD2 demonstrated increased beta desynchronization activity ipsilateral to the digit, regardless of tumor location. To assess language network engagement, we examine language laterality during an auditory verb generation task. Analysis of the shift in laterality index between scans demonstrated that tumors positioned ipsilaterally to the side of language dominance experienced a significantly greater shift when compared to tumors located in non-dominant hemisphere. Based on this study, neural activity in both motor and language networks appears to shift contralateral to the hemisphere containing the tumor.
Topic Area: METHODS: Neuroimaging