Poster E41, Monday, March 27, 2:30 – 4:30 pm, Pacific Concourse
Electrophysiological Correlates of Reward Processing, Error Monitoring and Preferences
James Germi1, Bradley Lega1; 1UT Southwestern Medical Center
The orbitofrontal cortex (OFC) and anterior cingulate cortex (ACC) have been implicated in reward processing and error monitoring. Eleven patients undergoing stereoencephalography (sEEG) recording for the treatment of medically-refractory epilepsy participated in a reward task to study the electrophysiological biomarkers of reward processing and individual preferences. We present the oscillatory signatures of reward processing and error monitoring across the time-frequency domain for the medial and lateral OFC and the ACC. While the medial OFC shows decreased low frequency activity and increased high frequency activity for positive feedback relative to negative feedback, the lateral OFC shows decreased low frequency activity and increased high frequency activity for negative feedback relative to positive feedback. The ACC shows broad relative increases across the time-frequency domain during negative feedback. Analyzing activity in these three regions simultaneously, we found that the ACC shows greater functional connectivity with the lateral OFC than the medial OFC and that these two regions are more strongly connected during negative feedback. Further, we found that high-frequency activity (HFA) in the medial and lateral OFC during the second half of feedback presentation was positive correlated with subjects’ preference levels while HFA in the ACC was negatively correlated with subjects’ preference levels. Analyzing simultaneous recordings from these three regions revealed that the ACC has greater functional connectivity with the lateral OFC than the medial OFC. These findings expose neural correlates of preferences and provide insight into the neural networks that underlie reward processing and preferences.
Topic Area: EXECUTIVE PROCESSES: Monitoring & inhibitory control