Poster D31, Monday, March 27, 8:00 – 10:00 am, Pacific Concourse
Trait impulsivity is associated with functional connectivity of striatal-frontal circuits differentially in smokers and nonsmokers
Sufang Li1, Xiaochu Zhang1, Betty Jo Salmeron1, Hong Gu1, Elliot Stein1, Yihong Yang1; 1Neuroimaging Research Branch, National Institute on Drug Abuse, NIH
Ventral striatum (VS) is a key structure implicated in impulsivity. Impulsivity is a multi-facet trait and it must interact with other brain regions to modulate impulsive behaviors. However, little is known about how it interacts with other brain regions underlies impulsivity in addiction. Resting state functional connectivity (rsFC) provided us a novel method to explore the association between impulsivity and intrinsic functional connectivity of VS circuits, and the potential alterations in smokers. 60 smokers and 60 nonsmokers participated in the rs-fMRI scan and their impulsivity was assessed. Voxel-wise rsFC between VS and all other brain regions were computed. ANOVA was then conducted to identify the effect of smoking, trait impulsivity and their interactions. Significant interactions were found in the dorsal anterior cingulate cortex (dACC) and bilateral amygdala. Specifically, positive correlation between impulsivity and rsFC of VS-amygdala circuit was found in smokers while not in nonsmokers; positive correlation between impulsivity and rsFC of VS-dACC circuit was found in nonsmokers but not in smokers. To further explore the role of these rsFC in impulsivity, subjects performed two tasks: Go/NoGo task and emotional task. rsFC of VS positively correlated with the activation in the amygdala (negative - positive); and also positively correlated with the activation in the dACC during failed inhibition. Additionally, VS-dACC rsFC negatively predict nicotine dependence severity and VS-amygdala rsFC positively predict anxiety in smokers. These results provide new evidence for the theory that the role of frontal-striatal circuit involved in impulse control, and striatal-limbic circuit involved in impulse drive.
Topic Area: EMOTION & SOCIAL: Other