Poster F50, Tuesday, March 28, 8:00 – 10:00 am, Pacific Concourse
Superior Longitudinal Fasciculus and Working Memory Functions Post Stroke: A Diffusion Tensor Imaging Study
Parminder Kaur1, Alexandra L. Borstad1, Petra Schmalbrock2, Nick Hohman1, Deborah S. Nichols-Larsen1; 1School of Health and Rehabilitation Sciences, The Ohio State University, 2Department of Radiology, College of Medicine, The Ohio State University
Objective: To study the: 1) structural connectivity changes in the superior longitudinal fasciculus (SLF) and inferior longitudinal fasciculus (ILF) poststroke and 2) relation of these networks’ integrity to cognitive, somatosensory and manual dexterity function. Methods: 12 chronic post-stroke subjects and 12 age, gender and handedness matched controls were enrolled and evaluated on Paced Auditory Serial Addition Test (PASAT), Hand Active Sensation Test (HASTe), Brief Kinesthesia Test (BKT), Manual Form Perception Test (MFP) and Box and Block Test (BBT). Diffusion Tensor Imaging (DTI) data was collected for all subjects, and Tract-based spatial statistics (TBSS) were used to examine the DTI data. Fractional anisotropy (FA) and mean diffusivity (MD) of the left and right SLF and ILF were evaluated. Results: There was a significant difference between groups on SLF FA and SLF MD values and, across the whole group SLF MD correlated with the HASTe (r=-0.588, 0.002), MFP (r=0.572, 0.004), PASAT (r=-0.587, 0.005), and BKT (r= -0.510, 0.011) scores. Conclusion: SLF’s altered white matter impacts working memory for cognitive, sensory discrimination and kinesthesia, which contributes to poorer recovery of hand dextrerity function.
Topic Area: EXECUTIVE PROCESSES: Working memory