Poster A139, Saturday, March 25, 5:00 – 7:00 pm, Pacific Concourse
Transcriptome analysis identifies blood biomarkers in the middle cerebral artery occlusion non-human stroke model
Sung S. Choi1, Eui-Jin Lee2, Sang-Hoon Cha3, Sang-Rae Lee4, Kyung Sik Yi3, Da H. Kim1, So H. Kim1, Joo L. Park1, Youngjeon Lee4, Kyu-Tae Chang4, Hong J. Lee1; 1Biomedical Research Institute, Chung-Ang University College of Medicine, Seoul, Korea, 2Institute of Catholic Integrative Medicine (ICIM), Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea, 3Department of Radiology, Chungbuk National University Hospital, Chungbuk, Republic of Korea, 4National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungju, Chungbuk, Korea
Ischemic stroke leads to long-term disability and finally death worldwide. Many preclinical trials were tried to overcome this disease in stroke animal model including middle cerebral artery occlusion model. In ischemic stroke, blood-based biomarkers may be applied for the diagnosis of ischemic origin and subtype, prediction of outcomes and targeted treatment. We observed consistently healthy rhesus macaques subjected to middle cerebral artery occlusion. Transcriptome were analyzed from 3 monkey samples. Several thousands of genes showed the significant changes of their expression levels after reperfusion. Hypoxia, immune response, angiogenesis, autophagy-related genes were changed significantly in these blood biomarkers. These results suggested that these fundamental data may provide the biomarkers in acute stage of stroke.
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