Impulsivity and Apathy Predict Involvement of Inhibitory Control Regions During Cognitive Interference
Emily Hahn1, Julia Felicione1, Aishwarya Gosai1, Matthew Boggess1, Alex Rockhill1, Amy Peters2, Alik Widge1, Darin Dougherty1, Thilo Deckersbach1; 1Massachusetts General Hospital/Harvard Medical School, 2University of Illinois at Chicago
While impairments in cognitive processing are prevalent across neurologic disorders of the CNS, transdiagnostic approaches reveal similar impairments in many psychiatric diagnosis. Disinhibition and apathy are both neurocognitive symptoms involving goal-directed behavior, and are particularly impaired in mood disorders such as bipolar disorder or depression. For this study, seventy six total subjects (mean age=35, sd=12) including unipolar bipolar patients (n=38) and healthy subjects were scanned using fMRI while participating in the Multi-source Interference Task (MSIT) superimposed on valenced IAPS pictures. The Frontal Systems Behavioral Scale was used to assess cognitive processing phenotypes. Results reveal lower impulsivity and higher apathy predict higher activation in regions during the interference condition of the MSIT/IAPS task, collapsed across valence. Namely, higher insula activity during interference was predicted by higher apathy scores (r=.35, p=.03). Conversely, higher dACC activation during interference was predicted by lower disinhibition scores (r=-.34, p=.04). Interestingly, no similar trends were found among healthy participants. That said, neural regions elicited by cognitive conflict and apathy are further corroborated, thus supporting linkage to neuropsychological constructs . Taken together, the importance of evaluating cognitive dysfunction in addition to symptoms commonly seen in mood disorders is highlighted and may help provide meaningful insight into transdiagnostic and therapeutic regimens.
Topic Area: EMOTION & SOCIAL: Emotion-cognition interactions