Poster C100, Sunday, March 26, 5:00 – 7:00 pm, Pacific Concourse
Brain activity underlying reactivation of episodic memories following lesion of the right temporal lobe
Corinna Haenschel1, Nareg Khachatoorian1, Danai Dima1, Shona Illingworth2, Catherine Loveday3, Martin Conway1; 1City University London, London, UK, 2University of Kent, UK, 3University of Westminster, London UK
Despite a large mainly right-side temporal lobe lesion, patient Claire (age: 51) can form memories of everyday experiences but rapidly, within 24 to 72 hours, loses access to them. Claire has used a neck-worn camera (SenseCam, SC) that automatically takes wide-angle colour photographs to improve her episodic memory. However, the underlying neurophysiological mechanisms of remembering these photos have not been studied. We tested Claire’s episodic memory in response to SC photos using electroencephalography (EEG) in comparison to 12 typical age-matched controls. One week after a predefined 2-hour sightseeing tour, participants EEG was recorded while they viewed short sequences of four pictures that were either taken from their tour, or were novel. For each photo, they were asked to make a recognition judgement, and to judge whether their recognition experience was one of familiarity or recollection. Claire also repeated the task with a second tour but with just an hour between the tour and the EEG recognition test. Control participants showed a decrease in familiarity and an increase in recollection within the sequence of four pictures. Claire showed a similar pattern of remembering to the controls when tested on the same day, but remembered very little after 1 week. In comparison to controls, Claire showed a larger visual and frontal response to recognition, but reduced response on the right parietal side. These data suggest that Claire uses compensatory mechanisms when recognizing the SC photos, drawing from visual and frontal areas and shed light into why SC photos improve her episodic memory.
Topic Area: LONG-TERM MEMORY: Episodic