Poster E134, Monday, March 27, 2:30 – 4:30 pm, Pacific Concourse
Feedback blunting due to sleep deprivation is affected by dopaminergic genotype
Hans Van Dongen1, John Hinson1, Paul Whitney1, Brieann Satterfield1, Michelle Schmidt1, Jonathan Wisor1; 1Washington State University
Sleep deprivation (SD) degrades dynamic decision making that requires flexible updating of decision-relevant information based on choice outcome feedback and reduces physiologic responsivity to feedback. Dopamine is a key neurotransmitter in neural pathways supporting learning and motivation and is likely to be involved in decision making degraded by SD. We investigated whether dynamic decision making during SD is affected by the Val158Met polymorphism of the Catechol-O-Methyltransferase (COMT) gene. Healthy subjects participated in a controlled laboratory study of SD. At baseline and again 24 h later during SD or well-rested control, subjects performed a go/no-go reversal learning (GNGr) task that required subjects to learn the stimulus-response mapping from feedback. About two-thirds of the way through the task, the stimulus-response mapping was reversed unexpectedly, which required subjects to learn the new stimulus-response mapping from choice outcome feedback. GNGr performance was quantified by discriminability (d') between go and no-go stimuli before and after stimulus-response reversal. GNGr performance did not differ by genotype at baseline. However, compared to subjects heterozygous or homozygous for the Met allele, subjects homozygous for the Val allele had significantly worse GNGr performance during SD. Moreover, their GNGr performance during SD after stimulus-response reversal was no better than chance. Thus, SD exposed a substantial vulnerability in dynamic decision making in individuals with the Val/Val genotype. This finding corroborates the idea that a dopaminergic pathway is involved in the SD-induced impairments in decision making that requires flexible updating of decision-relevant information and the reduced physiologic responsivity to feedback from choice outcomes.
Topic Area: THINKING: Decision making