Poster A101, Saturday, March 25, 5:00 – 7:00 pm, Pacific Concourse
Emerging EEG/ERP Methods: New Potential for Tobacco Science
Mauricio Rangel-Gomez1, Raul Cruz-Cano1, Pamela Clark1, Edward Bernat2; 1School of Public Health, University of Maryland, College Park, 2Department of Psychology, University of Maryland, College Park
EEG/ERP measures have proven useful for indexing differential effects of tobacco product characteristics, and emerging time-frequency (TF) signal processing approaches offer a number of advantages with the potential to further advance work in this area. TF approaches were applied to index changes in brain processing (N=31) during a common oddball task, before and after consuming smokeless products to satiation. Products were manipulated in a 2 (nicotine, no-nicotine) x 2 (flavor, unflavored) within-subjects design. TF decomposition allowed to determine activity in: delta (0-3 Hz), theta (4-7 Hz), alpha (8-12 Hz), and gamma (30-50 Hz). Delta activity, evidenced significant differences in visual processing areas for both flavor and nicotine, suggesting changes in visual attention and engagement in the task. Theta activity was significantly related to both flavor and nicotine. Theta activity was consistent with the N2 component, N2 is widely understood to index orienting and novelty processing with sources in the anterior cingulate cortex (ACC). Alpha activity was related to nicotine and not flavor, with decreases observed for nicotine relative to no-nicotine. Alpha has been shown to index inhibitory activity, such that when engagement in the increases, alpha decreases. Gamma activity was associated with flavor and not nicotine, although the pattern was more complex. Here early gamma activity (0-250 ms) evidenced an increase in amplitude, and late (500-1000 ms) decreases in amplitude, for flavor relative to unflavored.
Topic Area: METHODS: Electrophysiology