Poster B115, Sunday, March 26, 8:00 – 10:00 am, Pacific Concourse
Elevated inflammation associated with reduced brain volume and white matter integrity in the Coronary Artery Risk Development in Young Adults Study
Aoife O'Donovan1,2, Allison Kaup1,2, Lenore Launer3, Stephen Sidney4, Kristine Yaffe1,2; 1University of California, San Francisco, 2San Francisco VA Medical Center, 3National Institute on Aging, 4Kaiser Permanente Northern California
Elevated inflammation is associated with mild cognitive impairment and dementia, but the neural underpinnings of these associations are poorly understood. In older adults, higher inflammation has been associated with reduced brain volume and white matter integrity. Here, we examined if inflammation is associated with brain structure in midlife. Participants were 719 adults from the Coronary Artery Risk Development in Young Adults (CARDIA) study who underwent brain MRI at the Year 25 Exam (M age = 50.3±3.5; range 42-56; 48% male; 40.5% Black and 59.5% White). Inflammation was indexed by log-transformed C-reactive protein (CRP) measured concurrent with, and 5, 10 and 18 years before, MRI. Hierarchical linear regression was used to examine cross-sectional and prospective associations of CRP with brain volume and white matter integrity measures. All models were adjusted for age, sex and race, and brain volume models were additionally adjusted for intracranial volume. CRP was cross-sectionally associated with reduced total brain volume (β = -.03, p = .004), reduced gray matter volume (β = -.03, p = .03), higher white matter mean diffusivity (β = .10, p = .01) and lower white matter fractional anisotropy (β = -.09, p = .02), but not with white matter volume or white matter hyperintensities. CRP was not prospectively associated with MRI measures. Findings remained the same when excluding participants with CRP > 10mg/L. Links between inflammation and reduced brain volume and white matter integrity are evident in midlife. A better understanding of these links may inform new interventions.
Topic Area: NEUROANATOMY