Poster D130, Monday, March 27, 8:00 – 10:00 am, Pacific Concourse
The Relationship of Intraoperative EEG Measures with Pre & Postoperative Cognitive Function
Jacob E. Gardner1, Charlie M. Giattino1, Kenneth C. Roberts1, Faris M. Sbahi1, Miles Berger1, Marty G. Woldorff1; 1Duke University
Every year, more than 16 million Americans over age 60 undergo general anesthesia for surgery. Up to 40% of these older patients develop postoperative cognitive dysfunction (POCD), a syndrome of cognitive deficits that can last for weeks to months, or even more permanently, following surgery. Currently there are no intraoperative physiological predictors for identifying patients at risk for developing POCD. General anesthesia profoundly changes activity in the EEG alpha band (8-12 Hz), including its distribution across the scalp: frontal alpha power typically increases while posterior alpha decreases, a process termed anteriorization. We hypothesized that intraoperative alpha activity patterns—such as anteriorization—would differ across patients, and that these patterns would correlate with pre- and/or postoperative cognitive scores. To test these hypotheses, we collected pre- and intraoperative 32-channel EEG on patients over age 60 undergoing general anesthesia for surgery. We examined whether changes in alpha power and/or scalp distribution during anesthesia correlated with neurocognitive data collected before and six weeks after surgery, as well as if they predicted POCD. Preliminary results indicate that low intraoperative frontal alpha power significantly correlates with lower preoperative cognitive performance (rs = 0.79, p = 0.02) and trends toward a significant correlation with lower cognitive scores six weeks after surgery (rs = 0.67, p = 0.07). These data suggest that intraoperative EEG parameters can be used to predict a patient’s preoperative and postoperative cognitive status, as well as to possibly help understand the relationship between neural activity and cognitive resilience as we age.
Topic Area: THINKING: Development & aging