Poster F103, Tuesday, March 28, 8:00 – 10:00 am, Pacific Concourse
Effects of age on extrastriatal dopamine D2 receptor availability are overestimated without partial volume correction
Jennifer L. Crawford1, Kendra L. Seaman1, Aishwarya Vijay1, David Matuskey1, Evan D. Morris1, Gregory R. Samanez-Larkin1; 1Yale University
Prior studies have reported a marked decline in dopamine D2-like receptor availability across the adult life span in extrastriatal regions, however, almost none have accounted for age-related structural brain changes when quantifying dopamine receptor availability across adulthood. We used [11C] FLB 457, a high affinity D2/3 radioligand, to quantify dopamine receptor binding across frontal, parietal, temporal and occipital cortices, in addition to the hippocampus, amygdala, and thalamus. The positron emission tomography (PET) data were partial volume corrected (PVC) to account for age-related structural changes prior to binding potential estimation and then compared to the binding potentials obtained without using PVC. We found that the non-PVC data overestimated the negative association between age and D2-like receptors in every region studied, underscoring the importance of accounting for age-related morphological brain changes through the use of PVC in PET studies of dopamine receptor availability that have wide variation in participant age.
Topic Area: METHODS: Neuroimaging