Poster A100, Saturday, March 25, 5:00 – 7:00 pm, Pacific Concourse
A novel paradigm for rapid and simultaneous evaluation of auditory and visual pathways
Andrew S. Kessler1, Kristina C. Backer1, Laurel A. Lawyer1, Sharon Coffey-Corina1, David P. Corina1, Lee M. Miller1; 1University of California, Davis
Electroencephalography (EEG) can provide objective assessments of auditory and visual sensory capabilities in children at risk for language and cognitive impairments. Existing EEG paradigms are often limited to measuring activity from one sensory domain at a time, may be time consuming, and may target only a subset of responses from that particular sensory domain (e.g., only auditory brainstem responses (ABR) or P1-N1 cortical auditory evoked potentials (CAEPs)). We have devised a passive EEG paradigm that provides a rapid and simultaneous assessment of early auditory and visual capabilities suitable for infants and children. Method. Subjects watch a centrally-presented silent cartoon flanked by a visual display of flickering rings at two eccentricities while an engineered auditory speech stimulus is presented (12 minutes). Visual stimuli are designed to elicit transient and steady-state visual evoked potentials. The use of high-contrast (black/ white) and isoluminant (red/green) visual displays differentially weight contributions of magnocellular and parvocellular visual pathways, while the multiplexed acoustic speech simultaneously assesses the ascending speech processing hierarchy. Results. We report EEG data from 25 healthy young adults, which validate the paradigm’s ability to reliably elicit ABR, middle latency, late latency (P1-N1), and steady state auditory responses. We find significant differences in the spectral pattern of the visual steady state responses when comparing high-contrast and isoluminant visual conditions. The unique topographies of auditory and visual responses are highlighted. Conclusion. These data demonstrate a child-friendly EEG paradigm that assesses the integrity of early auditory and visual sensory systems and is sensitive to cross-modal interactions.
Topic Area: METHODS: Electrophysiology