Poster F113, Tuesday, March 28, 8:00 – 10:00 am, Pacific Concourse
Domain-specific accuracy of the Montreal Cognitive Assessment and the Mattis Dementia Rating Scale-2 in Parkinson’s disease
Taylor Hendershott1, Delphine Zhu1, Seoni Llanes1, Kathleen Poston1,2; 1Department of Neurology and Neurological Science, Stanford University School of Medicine, 2Department of Neurosurgery, Stanford University School of Medicine
Individuals with Parkinson’s disease (PD) have an increased risk of developing cognitive impairment (CI). Due to limited time and resources in research and clinical settings, global cognitive assessments, such as the Montreal Cognitive Assessment (MoCA) and Mattis Dementia Rating Scale-2 (DRS), are sometimes used to diagnose CI in lieu of a full neuropsychological battery. These tests contain subtests aimed to measure specific cognitive functions, but there are no published data assessing the domain specific accuracy of the MoCA and DRS. To examine this, we administered a MoCA and DRS to 85 PD participants, along with a neuropsychological battery that assessed five cognitive domains: attention/working memory, executive function, episodic memory, language, and visuospatial. Using published criteria, we defined CI as more than 1.5 standard deviations below the mean on at least two tests. Participants were categorized as PD without CI (n=45) or PD with CI (n=40). Using the receiver operating characteristic curve, the MoCA displayed a high sensitivity and specificity in identifying executive function impairment (89.3% and 82.5%), but was neither sensitive nor specific in identifying language (68.8% and 71.0%) and attention/working memory (59.1% and 79.4%) impairments. The DRS showed sensitivity, but not specificity in detecting domain-specific impairments for the attention (95.5% and 46.0%) and memory (79.5% and 50.0%) sections. The DRS construction section was sensitive but not specific (94.3% and 13.3%) in detecting visuospatial impairments. These results demonstrate that the MoCA and DRS are useful screening tools, but have limited domain specificity and therefore should be interpreted with caution.
Topic Area: METHODS: Other