Poster B113, Sunday, March 26, 8:00 – 10:00 am, Pacific Concourse
Differences in brain structures in healthy young smokers: an MRI volumetric study
Gergely Darnai1,2, Beatrix Lábadi1, András Zsidó1, Orsolya Inhóf1, Eszter Simon1, Eszter Kohn1, Gábor Perlaki3,4, Gergely Orsi3,4, Norbert Kovács2, József Janszky2,4, Tamás Bereczkei1; 1University of Pécs, Department of Psychology, Hungary, 2University of Pécs, Department of Neurology, Hungary, 3Pécs Diagnostic Centre, Pécs, Hungary, 4MTA-PTE Clinical Neuroscience MR Research Group, Pécs, Hungary
Growing evidence from animal and human neuroimaging studies indicates functional and structural brain-altering effects of smoking. Investigations in humans found wide range of effects but studies focusing on young healthy population are sparse. We used structural magnetic resonance imaging technique for assessing volumetric differences between 18 smokers (9 males) and 18 age- and gender-matched controls. Significantly smaller grey matter volumes (p = 0.05, corrected for intracranial volume) were found in anterior and posterior cingulate, and parahippocampal cortex in smokers, although greater insular and orbitofrontal volumes were found also in people with nicotine addiction. Group differences were found in corpus callosum, bilateral pallidum, bilateral cerebellum and right accumbens - non-smokers showed greater volumes in every subcortical region. These findings provide evidence for cognitive dysfunctions and alterations in cognitive control function in earlier stages of life.
Topic Area: NEUROANATOMY