Poster E44, Monday, March 27, 2:30 – 4:30 pm, Pacific Concourse
Examining the Functional Network Structure of the Frontal Lobes Across Domains of Cognition
Jordan Garrett1, Robert Blumenfeld1; 1California State Polytechnic University, Pomona
The frontal lobes implement control operations fundamental to flexible, goal-driven behavior. In the human, at least 19 cytoarchitectonically unique subregions comprise the frontal lobes, and a major aim of cognitive neuroscience has been to characterize the functional organization of these subregions. The aim of the present study was to investigate the topology of frontal lobes by examining patterns of co-activation amongst frontal subregions across a large number of studies in the neuroimaging literature. Using the BrainMap database, which contains activation foci from a large (>1600) set of studies in the neuroimaging literature, we derived meta-analytic co-activation matrices of the frontal lobes for the several specific cognitive domains (Memory, Attention, Working Memory, Language, Audition, Vision). Our initial results show several specific ways in which the functional wiring of frontal subregions varied according to behavioral domain. First, the density of these networks varied considerably with behavioral domain. Second, the modular structure of these networks varied considerably. Third, the anatomical location of some, but not all, central hub nodes varied with cognitive domain. In general, our initial results lend further credence to the notion that the frontal lobes as a whole, support domain-general control processing, however its functional wiring is highly adaptable and potentially allows different network configurations to support specialized domain-specific processes.
Topic Area: EXECUTIVE PROCESSES: Working memory