Poster C91, Sunday, March 26, 5:00 – 7:00 pm, Pacific Concourse
Associations between region-specific structural brain integrity and cognitive abilities in old age: A multivariate, longitudinal, structural equation modeling approach
Sandra Düzel1, Andreas Brandmaier1,2, Simone Kühn3, Ulman Lindenberger1,2; 1Max Planck Institute for Human Development, Berlin, Germany, 2Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany, 3University Clinic Hamburg-Eppendorf, Hamburg, Germany
Older individuals differ greatly in cognitive functioning, and these differences are assumed to reflect differences in the structural integrity of specific brain regions. However, delineating change-change associations between brain and behavior has often been elusive. We apply multivariate latent difference modeling to two-occasion longitudinal data from the Berlin Aging Study II to examine the extent to which individual differences in level and change of region-specific latent constructs of structural brain integrity in hippocampus (HC), prefrontal cortex (PFC) and occipital cortex (OCC) are related to individual differences in latent constructs of cognitive abilities representing episodic memory (EM), working memory (WM), and fluid intelligence (Gf). Full-information maximum likelihood was used to also include individuals who had not participated in MR imaging session. The total sample consisted of 1537 healthy older individuals aged 61 to 88 years, and the imaging subsample of 342 individuals aged 61 to 82 years. Region-specific factors of brain integrity were based on T1-weighted, magnetization transfer, an diffusion imaging as fallible indicators of local gray matter tissue density, solid proton pool, and mean diffusivity of water, respectively. Initial modeling results show that higher levels of EM and HC integrity were associated with less decline in HC integrity. This finding is consistent with the hypothesis that hippocampal integrity helps to to maintain EM in old age.
Topic Area: LONG-TERM MEMORY: Development & aging