Poster D17, Monday, March 27, 8:00 – 10:00 am, Pacific Concourse
Evidence for error feedback control during intrinsic neuromodulation of emotion.
Keith Bush1, Josh Cisler2, Andrew James1, Clint Kilts1; 1University of Arkansas for Medical Sciences, 2University of Wisconsin - Madison
Real-time functional magnetic resonance imaging (rtfMRI), when used to generate brain activation feedback to guide volitional control (rtfMRI-guided intrinsic neuromodulation), reflects a cognitive error feedback control system that is subject to the principles defined by engineering control theory. We conducted retrospective control theoretic analysis of data related to rtfMRI-guided neuromodulation of emotional response to traumatic/stressful memories to test this hypothesis. We identified neural structures related to core control components: error processing and control law (the mapping of error signals to error-minimizing control decisions). Independent components containing anterior cingulate cortex as well as lateral prefrontal cortex, anterior insula, and striatum were linked to the control system’s internal and external (feedback) error processing units, respectively. Combined, internal and external error processing predicted 57% of group performance variance for the task. Control law analysis further implicated the frontoparietal network (FPN) in the translation of error signals to task-specific cognitive dynamic changes. Moreover, neural activation within the external error processing system, which is recruited exclusively by rtfMRI-guided neuromodulation, was shown to recruit FPN activation more strongly than internal error processing, suggesting a neural explanation for the efficacy of guided over unguided neuromodulation. Based on the neuroanatomical structures involved, rtfMRI-guided neuromodulation exhibits strong functional ties to cognitive control, which was recently posited as a mechanism explaining both the onset and successful treatment of psychiatric illness and cognitive deficit. Therefore, understanding how these mechanisms interact, as well as their potential manipulation via rtfMRI-based feedback, may have positive future implications for psychiatric and psychological therapeutics.
Topic Area: EMOTION & SOCIAL: Emotion-cognition interactions