Poster C66, Sunday, March 26, 5:00 – 7:00 pm, Pacific Concourse
Thinning of the Left Middle Temporal Gyrus is Associated with Word Retrieval Difficulties in Tempora
Clara Yoon1, Victor Kang1, Joo Sung Yi1; 1New York University
Epilepsy is the fourth most common neurological disorder, with temporal lobe epilepsy (TLE) accounting for 60% of all epileptic diagnoses. The temporal lobe is also involved in language processing, and TLE patients often demonstrate language impairments, suggesting that damage to the temporal lobe, particularly the middle temporal gyrus, may lead to observed language impairments. However, a direct link has not yet been established. Thus, the present study 1) compared differences in middle temporal gyrus cortical thickness (MTGCT) between TLE patients and controls, 2) compared differences in language aptitude, assessed by the Boston Naming Test (BNT), between left-lateralized TLE (L-TLE) patients and controls, and 3) correlated MTGCT with language aptitude in L-TLE patients. Relative to controls, TLE patients were found to have decreased MTGCT localized to the hemisphere that was ipsilateral to their seizure onset zone. Reduced MTGCT was directly associated with decreased BNT performance in L-TLE patients. In combination, these results show that TLE is accompanied by cortical atrophy and impaired language if the side of the seizure focus is in the left (language dominant) hemisphere, supporting the view that language impairment and diminished structural integrity of the middle temporal gyrus are a result of localized seizure activity in TLE.
Topic Area: LANGUAGE: Other