Poster F98, Tuesday, March 28, 8:00 – 10:00 am, Pacific Concourse
Non-invasive Brain Imaging Biomarkers in Sudden Unexpected Death in Epilepsy Patients (SUDEP)
Chaeyeon Kim1, Justin Jangyoon Choi1, Richard Lee1; 1New York University
Sudden Unexpected Death in Epilepsy Patients (SUDEP), a phenomenon in which postmortem analysis does not reveal a structural or toxicological cause for death, is one of the leading causes of death in epilepsy patients. Regions of the brain that regulate autonomic functions have been thought to play a role in the onset of SUDEP. The purpose of this investigation was to compare SUDEP patients’ MRIs with those of healthy and TLE patient controls to discover any significant biomarkers that might indicate a tendency to SUDEP. This investigation used fMRI scans to measure fALFF, ALFF, and VBM values and yielded results that confirmed the link between autonomic function and the incidence of SUDEP, reflecting findings from previous studies. Statistically significant z-scores indicated 1) enlarged pons, pallidum, and caudate regions and 2) lower functional activity in the putamen region. These brain regions have been found to be responsible for the regulation of cardiac and respiratory functions. In the future, these integrated methods can be employed to create tailored biomarkers for each patient, potentially saving countless lives from SUDEP. In summary, these results provide evidence that MRI biomarkers may be a useful clinical tool in the differential diagnosis of SUDEP patients and show potential for wider applicability to other neurological diseases.
Topic Area: METHODS: Neuroimaging