Poster D43, Monday, March 27, 8:00 – 10:00 am, Pacific Concourse
Effect of a dopaminergic antagonist on the drives to perform extraordinary roles
Tim Hadjis1,3, Gifty Asare1,3, Ana Fernandez-Cruz4, Ola Mohamed Ali1,3, Ishan Walpolla1,3, Julia Segal1,3, Bruno Debruille1,2,3; 1Department of Psychiatry, McGill University, Montreal, QC, Canada, 2Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada, 3Douglas Mental Health University Institute, Montreal, QC, Canada, 4McGill University Integrated Program in Neuroscience, Montréal, QC, Canada
The will to play extraordinary social roles in healthy participants could be a factor of the symptoms measured in the continuum existing from normality to schizophrenia. In a previous study, healthy participants who accepted a greater percentage of the extraordinary roles did it faster compared to those who accepted a lower percentage of such roles and had higher schizotypal personality (SPQ) scores. Here, we tested if dopaminergic antagonists act by changing the will to play extraordinary roles. Healthy volunteers were recruited to fill out questionnaires assessing schizotypal traits and were either given one minimal dose (i.e., 1 mg) of risperidone (N=45) or a placebo (N=37). They were then presented with hundreds of names of social roles and asked, for each of them, to decide whether or not they could consider playing it at any moment in their lives. Using a median split, participants were then divided into a group of high- and a group of low-accepters of extraordinary roles. In contrast to predictions, relative to placebo, risperdal increased the percentages of extraordinary roles accepted in the high- and not in the low-accepter group (F(1,70)=8.012, p=0.006). Risperidone also increased the percentages of favorable roles accepted in the high- but not in the low-accepter group (F(1,70)=4.919, p=0.03). Nevertheless, risperidone delayed acceptance and rejections in high- and not in low-accepters for all types of social roles (F(1,76)=5.03, p=0.028). The results found here suggest that dopaminergic antagonists may change the drives to play social roles in high-accepters of extraordinary roles.
Topic Area: EXECUTIVE PROCESSES: Goal maintenance & switching