Poster A128, Saturday, March 25, 5:00 – 7:00 pm, Pacific Concourse
Memantine’s Effects on the Reconsolidation of Long-term Methamphetamine Associated Memories
Michael Hanna1, Paige Braden1, Brittanie Clarke1, Hunter Goehring1; 1Vanguard University
Relapse rates for those struggling with drug addictions are relatively high due to strong craving induced by exposure to cues that have been previously associated with drug administration. Drug associated memories are formed through the process of consolidation, the conversion of memories from a fragile state to a stable state. The reconsolidation hypothesis claims that when a stable, long-term memory is reactivated, it undergoes consolidation again in which the memory is in an unstable form. It has been shown that consolidation requires the activation of the NMDA glutamate receptor to initiate a cascade of cellular processes that leads to active synapses. In the current study, we aim to examine whether the NMDA receptor plays a role in the reconsolidation of long-term drug-associated memories. To address this question, we injected rats with the memantine, an NMDA receptor antagonist, in a conditioned place preference paradigm. Multiple injections of memantine immediately after reactivation of drug-paired memories attenuated preference for the drug-associated compartment. Our data also showed that the attenuating effects of memantine on drug-associated memories lasted long-term. Finally, we also show that the time frame for reconsolidation interference with memantine is between 0 to 6 hours. Our data suggest that the reconsolidation of drug-associated memories are dependent on the NMDA receptor, with implications for a potential novel pharmaceutical treatment for drug addiction.
Topic Area: LONG-TERM MEMORY: Semantic